Fibroblast Growth Factor 21 Suppresses Adipogenesis in Pig Intramuscular Fat Cells
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منابع مشابه
Fibroblast Growth Factor 21 Suppresses Adipogenesis in Pig Intramuscular Fat Cells
Fibroblast growth factor 21 (FGF21) plays an important role in the treatment of disease associated with muscle insulin resistance which is characterized by various factors, such as intramuscular triglyceride (IMT) content. Studies have also shown that FGF21 inhibits triglyceride synthesis in vivo. However, the precise mechanism whereby FGF21 regulates triglyceride metabolism in intramuscular fa...
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Obesity, with its related problems, is recognized as the fastest growing disease epidemic facing the world, yet we still have limited insight into the regulation of adipose tissue mass in humans. We have previously shown that adipose-derived microvascular endothelial cells (MVECs) secrete a factor(s) that increases proliferation of human preadipocytes. We now demonstrate that coculture of human...
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BACKGROUND One of the main challenges in skin flap surgery is tissue ischemia and following necrosis. The present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. METHODS Thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal rando...
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A new report in this issue of Diabetes provides evidence that at least some metabolic actions of glucagon may be mediated by fibroblast growth factor 21 (FGF21). Habegger et al. (1) report that native glucagon raises plasma FGF21 levels in human subjects, confirming the report by Arafat et al. (2). They also find that a synthetic glucagon receptor agonist (IUB288) upregulates FGF21 expression i...
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OBJECTIVE Reports of increased circulating fibroblast growth factor 21 (FGF21) levels in obesity indicate that FGF21 may be implicated in body weight homeostasis. We sought to investigate the existence of FGF21 in human cerebrospinal fluid (CSF) and, if present, the relationship between CSF FGF21 with body adiposity and metabolic parameters. RESEARCH DESIGN AND METHODS CSF and corresponding p...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2015
ISSN: 1422-0067
DOI: 10.3390/ijms17010011